ARTICOLI ORIGINALI

1. Liu H, Norman GL, Shums Z, Worman HJ, Krawitt EL, Bizzaro N, Vergani D, Bogdanos DP, Dalekos GN, Milkiewicz P, Czaja AJ, Heathcote EJ, Hirschfield GN, Tan EM, Miyachi K, Bignotto M, Battezzati PM, Lleo A, Leung PS, Podda M, Gershwin ME, Invernizzi P . PBC Screen: an IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis.  J Autoimmun 2010;35:436-442.
2. Liu L, Liu Y, Wang L, Xu D, Lin B, Zhong R, Gong S, Podda M, Invernizzi P . Prevalence of primary biliary cirrhosis in adults referring hospital for annual health check-up in Southern China.  BMC Gastroenterology 2010;10:100.
3. Bernuzzi F, Fenoglio F, Battaglia F, Fravega M, Gershwin ME, Indiveri F, Ansari AA, Podda M, Invernizzi P * (*uguale contributo), Filaci G*. Phenotypical and functional alterations of CD8 regulatory T cells in primary biliary cirrhosis.  J Autoimmun 2010;35:176-180.
4. Liu X*, Invernizzi P * (*uguale contributo), Lu Y, Kosoy R, Lu Y, Bianchi I, Podda M, Xu C, Xie G, Macciardi F, Selmi C, Lupuli S, Shigeta R, Ransom M, Lleo A, Lee AT, Mason AL, Myers RP, Peltekian KM, Ghent CN, Bernuzzi F, Zuin M, Italian Consortium for Primary Biliary Cirrhosis Genetics ICPBCG, Gregersen PK, Heathcote E-J, Hirschfield GM, Siminovitch KA, Amos CI, Gershwin ME, Seldin MF. Genome-wide meta-analyses identifies three loci associated with primary biliary cirrhosis.  Nat Genet 2010;42:658-60.
5. Lleo A, Bowlus CL, Yang GX, Invernizzi P , Podda M, Van de Water J, Ansari AA, Coppel RL, Worman HJ, Gores GJ, Gershwin ME. Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis.  Hepatology 2010;52:987-98.
6. Montali L, Tanaka A, Riva P, Takahashi H, Cocchi C, Ueno Y, Miglioretti M, Takikawa H, Vecchio L, Frigerio A, Bianchi I, Jorgensen R, Lindor KD, Podda M, Invernizzi P , and the Italian-Japanese PBC Study Group. A short version of a HRQoL questionnaire for Italian and Japanese patients with PBC.  Digest Liver Dis 2010;42:718-723.
7. Hov, JR, Lleo A, Selmi C, Woldseth B, Fabris L, Strazzabosco M, Karlsen TH, Invernizzi P . Genetic associations in Italian primary sclerosing cholangitis: Heterogeneity across Europe defines a critical role for HLA-C.  J Hepatol 2010;52:712-7.
8. Tanaka A, Nezu S, Uegaki S, Kikuchi K, Shibuya A, Miyakawa H, Takahashi S, Bianchi I, Zermiani P, Podda M, Ohira H, Invernizzi P * (*uguale contributo), Takikawa H*. Vitamin D receptor polymorphisms are associated with increased susceptibility to primary biliary cirrhosis in both Japanese and Italian populations.  J Hepatol 2009;50;1202-1209.
9. Lleo A, Selmi C, Invernizzi P , Podda M, Coppel RL, Mackay IR, Gores GJ, Ansari AA, Van de Water J, Gershwin ME. Apotopes and the biliary specificity of primary biliary cirrosis.  Hepatology 2009;49:871-879.
10. Invernizzi P , Selmi C, Poli F, Frison S, Floreani A, Alvaro D, Almasio P, Rosina F, Marzioni M, Fabris L, Muratori L, Qi L, Seldin MF, Gershwin ME, Podda M, and the Italian PBC Genetic Study Group. Human leukocyte antigen polymorphisms in Italian primary biliary cirrhosis: a multicenter study of 664 patients and 1992 healthy controls.  Hepatology 2008;48:1906-1912.
11. Alpini G, Invernizzi P , Gaudio E, Ventre J, Copriva S, Bernuzzi F, Onori P. Serotonin metabolism is dysregulated in cholangiocarcinoma: implications for tumor growth.  Cancer Research 2008;68:9184-9193.
12. Alvaro D, Macarri G, Mancino MG, Marzioni M, Franchitto A, Onori P, Ginanni-Corradini S, Attili AF, Invernizzi P , Gaudio E, Benedetti A. Biliary insulin like growth factor-1 (IGF1) is a sensitive marker for the diagnosis of extrahepatic cholangiocarcinoma.  Ann Inter Med 2007;147:451-9.
13. Miozzo M, Selmi C, Gentilin B, Sirchia S, Oertelt S, Zuin M, Gershwin ME, Podda M, Invernizzi P . Preferential X chromosome loss but random inactivation characterize primary biliary cirrhosis.  Hepatology 2007;46:456-62.
14. Wesierska-Gadek J, Penner E, Battezzati PM, Selmi C, Zuin M, Hitchman E, Worman HJ, Gershwin ME, Podda M, Invernizzi P . Correlation of initial autoantibody profile and clinical outcome in primary biliary cirrhosis.  Hepatology 2006;43:1135-1144.
15. Invernizzi P , Miozzo M, Selmi C, Persani L, Battezzati PM, Zuin M, Lucchi S, Meroni PL, Marasini B, Zeni S, Watnik M, Grati FR, Simoni G, Gershwin ME, Podda M. X chromosome monosomy: a common mechanism for autoimmune diseases. J Immunol 2005;175:575-578.
16. Invernizzi P , Miozzo M, Battezzati PM, Bianchi I, Grati FR, Simoni G, Selmi C, Watnik M, Gershwin ME, Podda M. The frequency of monosomy X in women with primary biliary cirrhosis.  Lancet 2004;363:533-535.
17. Invernizzi P , Setchell KDR, Crosignani A, Battezzati PM, Larghi A, O’Connell N, Podda M. Differences in the metabolism and disposition of ursodeoxycholic acid and of its taurine-conjugated species in patients with primary biliary cirrhosis.  Hepatology 1999;29;320-327 .
18. Invernizzi P , Crosignani A, Battezzati PM, Covini G, De Valle G, Larghi A, Zuin M, Podda M. Comparison of the clinical features and clinical course of antimitochondrial antibody-positive and negative primary biliary cirrhosis.  Hepatology 1997;25:1090-1095.

1. Invernizzi P , Selmi C, Gershwin ME. Update on primary biliary cirrhosis.  Digest Liver Dis 2010;42:401-408.
2. Lleo A, Invernizzi P , Gao B, Podda M, Gershwin ME. Definition of human autoimmunity – autoantibodies versus autoimmune disease.  Autoimmun Rev 2010;9:A259-A266.
3. Invernizzi P . Geoepidemiology of autoimmune liver diseases.  J Autoimmun 2009 ;34;J300-J306
4. Invernizzi P , Gershwin ME. The genetics of human autoimmune disease.   J Autoimmun 2009; 33:290-299
5. Invernizzi P , Pasini S, Selmi C, Gershwin ME, Podda M. Female predominance and X chromosome defects in autoimmune diseases.  J Autoimmun 2009;33:12-16.
6. Invernizzi P . Future directions in genetic for autoimmune diseases.  J Autoimmun 2009;33:1-2.
7. Invernizzi P * (*uguale contributo), Beuers U*, Boberg K*, Chapman R*, Chazouilleres O*, Jones DEJ*, Lammert F*, Pares A*, Trauner M*. EASL clinical practice guidelines on management of cholestatic liver diseases.  J Hepatol 2009;51:237-67
8. Lleo A, Invernizzi P , Zhong R, Gershwin ME. Etiopathogenesis of Primary Biliary Cirrhosis.  World J Gastroenterol 2008;1 4: 3328-3337
9. Crosignani A, Battezzati PM, Invernizzi P , Selmi C, Prina E, Podda M. Clinical Features and Management of Primary Biliary Cirrhosis.  World J Gastroenterol 2008; 14: 3313-3327.
10. Bogdanos DP, Invernizzi P , Mackay IR, Vergani D. Autoimmune liver serology: Current diagnostic and clinical challenges.  World J Gastroenterol 2008; 14: 3374-3387.
11. Invernizzi P , Mackay IR. Autoimmune liver diseases.  World J Gastroenterol 2008; 14: 3290-3291.
12. Invernizzi P , Lleo A, Podda M. Interpreting serological tests in diagnosing autoimmune liver diseases.  Semin Liver Dis 2007;27:161-172.
13. Invernizzi P , Selmi C, Ranftler C, Podda M, Wesierska-Gadek J. Antinuclear antibodies in primary biliary cirrhosis.  Semin Liver Dis 2005;25:298-310.
14. Invernizzi P , Selmi C, Mackay IR, Podda M, Gershwin ME. From bases to basis: Linking genetics to causation in primary biliary cirrhosis.  Clin Gastroenterol Hepatol 2005;3:401-410.
15. Selmi C*, Invernizzi P * (*uguale contributo), Miozzo M, Podda M, Gershwin ME. Primary biliary cirrhosis: does X mark the spot?  Autoimmun Rev 2004;3:493-499.