SELECTED PUBLICATIONS

1. Sacco MG, Zecca L, Bagnasco L, Chiesa G, Parolini C, Bromley P, Mira Catò E, Roncucci R, Clerici L, Vezzoni P. A transgenic mouse model for the detection of cellular stress induced by toxic inorganic compounds. Nature Biotech 15:1392-1397, 1997
2. Villa A, Santagata S, Bozzi F, Giliani S, Frattini A, Imberti L, Benerini Gatta L, Ochs HD, Schwarz K, Notarangelo L, Vezzoni P and Spanopoulou E. Partial V(D)J recombination activity leads to Omenn syndrome. Cell 93: 885-896, 1998
3. SaccoMG, Caniatti M, Mira Catò E, Frattini A, Chiesa G, Ceruti R, Adorni F, Zecca L, Scanziani E and Vezzoni P. Liposome-delivered angiostatin strongly inhibits tumor growth and metastatization in a transgenic model of spontaneous breast cancer. Cancer Res 60:2660-2665, 2000
4. Sacco MG,Ungari M, Mira Catò E, Villa A, Strina D, Notarangelo LD, Jonkers J, Zecca L, Facchetti F, Vezzoni P. Lymphoid abnormalities in CD40L transgenic mice suggest the need for tight regulation in gene therapy approaches to Hyper IgM syndrome. Cancer Gene Therapy, 7:1299-1206, 2000
5. Zucchi I, Bini L, Valaperta R, Ginestra A, Albani D, Susani L, Sanchez JC, Liberatori S, Magi B, Raggiaschi R, Hochstrasser DF, Pallini V, Vezzoni P, Dulbecco R. Proteomic dissection of dome formation in a mammary cell line: role of tropomyosin-5b and maspin. Proc. Natl. Acad. Sci. USA., 98:5608-5613, 2001
6. Zucchi I, Bini L, Albani D, Valaperta R, Liberatori S, Raggiaschi R, Montagna C, Susani L, Barbieri O, Pallini V, Vezzoni P, Dulbecco R. Dome formation in cell cultures as expression of an early stage of lactogenic differentiation of the mammary gland. Proc Natl Acad Sci U S A. 99:8660-8665, 2002
7. MusioA, MontagnaC, ZambroniD, IndinoE, BarbieriO, CittiL, VillaA, RiedT, VezzoniP. Inhibition of BUB1 results in genomic instability and anchorage-independent growth of normal human fibroblasts. Cancer Res, 63:2855-2863, 2003
8. Zucchi I, Prinetti A, Scotti M, Valsecchi V, Valaperta R, Mento E, Reinbold R, Vezzoni P, Sonnino S, Albertini A, Dulbecco R. Association of rat8 with Fyn protein kinase via lipid rafts is required for rat mammary cell differentiation in vitro. Proc Natl Acad Sci U S A. 101:1880-1885, 2004
9. Sacco MG, Amicone L, Mira Cato E, Filippini D, Vezzoni P, Tripodi M.Cell-based assay for the detection of chemically induced cellular stress by immortalized untransformed transgenic hepatocytes. BMC Biotechnol. 2004 Mar 19;4:5
10. Zucchi I, Mento E, Kuznetsov VA, Scotti M, Valsecchi V, Simionati B, Vicinanza E, Valle G, Pilotti S, Reinbold R, Vezzoni P, Albertini A, Dulbecco R. Gene expression profiles of epithelial cells microscopically isolated from a breast-invasive ductal carcinoma and a nodal metastasis. Proc Natl Acad Sci U S A. 101:18147-18152, 2004.
11. Musio A, Montagna C, Mariani T, Tilenni M, Focarelli ML, Brait L, Indino E, Benedetti PA, Chessa L, Albertini A, Ried T, Vezzoni P. SMC1 involvement in fragile site expression. Hum Mol Genet. 14:525-533, 2005
12. Frattini A, Blair HC, Sacco MG, Cerisoli F, Faggioli F, Mira Catò E, Pancrazio A, Musio A, Rucci F, Sobacchi C, Sharrow AC, Kalla SE, Buzzone MG, Colombo R, Magli MC, Vezzoni P, Villa A. Rescue of ATPa3-deficient Murine Malignant Osteopetrosis by Hematopoietic Stem Cell Transplantation In Utero. Proc Natl Acad Sci USA, 102:14629-14634, 2005
13. Musio A, Selicorni A, Focarelli ML, Gervasini C, Milani D, Russo S, Vezzoni P, Larizza L. X-linked Cornelia de Lange syndrome owing to SMC1L1 mutations. Nat Genet. 38:528-530, 2006
14. Sobacchi C, Frattini A, Guerrini MM, Abinun M, Pangrazio A, Susani L, Bredius R, Mancini G, Cant A, Bishop N, Grabowski P, Del Fattore A, Messina C, Errigo G, Coxon FP, Scott DI, Teti A, Rogers MJ, Vezzoni P, Villa A, Helfrich MH. Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL. Nat Genet. 39:960-962, 2007
15. Paulis M, Bensi M, Orioli D, Mondello C, Mazzini G, D'Incalci M, Falcioni C, Radaelli E, Erba E, Raimondi E, De Carli L. Transfer of a human chromosomal vector from a hamster cell line to a mouse embryonic stem cell line. Stem Cells. 25:2543-2550, 2007.

SOCIAL PUBLICATIONS

1. Dulbecco R, Raineri P, Vezzoni P, Lucchini F, Brovedani E, Fariello R. Clonazione: problemi etici e prospettive scientifiche. Le Scienze, suppl, maggio 1997
2. Dulbecco R. Vezzoni P, “Il progetto Genoma Umano”. Le Scienze, Quaderni-Dossier, marzo 1998
3. A. Bazzi, P. Vezzoni. “Biotecnologie della vita quotidiana”, Laterza, 2000
4. P. Vezzoni. “Intersezioni. Questioni biologiche di rilevanza filosofica”, McGrawHill, 2000
5. P. Vezzoni.  “Si può clonare un essere umano”, Laterza, 2003
6. P. Vezzoni. “Il futuro e il passato dell’uomo”, Bruno Mondadori, 2006
7. A Albertini, P. Vezzoni. “Biotecnologie”. In “Enciclopedia del Novecento”, Enciclopedia Italiana Treccani, 2004
8. P. Vezzoni. “Geni, evoluzione e malattie”. Le Scienze, dicembre 2007
9. P. Vezzoni. “Biotecnologie”.Enciclopedia della Scienza e della Tecnica,Enciclopedia Italiana Treccani, 2008, in corso di stampa

SELECTED PUBLICATIONS - Dr. Paolo Vezzoni

1. Villa A, Notarangelo LD, DiSanto JP, Macchi PP, Strina D, Frattini A, Lucchini F, Patrosso MC, Giliani S, Mantuano E, Agosti S, Nocera G, Kroczek RA, Fischer A, Ugazio AG, G de St Basile, Vezzoni P. Organization of the human CD40L gene: implications for molecular defects in X-linked hyper-IgM syndrome and prenatal diagnosis.   Proc Natl Acad Sci USA 91:2110-2114, 1994
2. Villa A, Notarangelo L, Macchi P, Mantuano E, Cavagni G, Brugnoni D, Strina D, Patrosso MC, Ramenghi U, Sacco MG, Ugazio A , Vezzoni P. X-linked thrombocytopenia and Wiskott-Aldrich syndrome are allelic diseases with mutations in the Wasp gene. Nature Genet 9:414-417, 1995
3. Macchi P, Villa A, Giliani S, Sacco MG, Frattini A, Porta F, Ugazio A, Johnston J, Candotti F, O' Shea J, Vezzoni P, Notarangelo G. Mutations of JAK3 gene in patients with autosomal severe combined immunodeficiency (SCID).    Nature 377:65-68, 1995
4. Sacco MG, Zecca L, Bagnasco L, Chiesa G, Parolini C, Bromley P, Mira Catò E, Roncucci R, Clerici L, Vezzoni P. A transgenic mouse model for the detection of cellular stress induced by toxic inorganic compounds. Nature Biotech 15:1392-1397, 1997
5. Villa A, Santagata S, Bozzi F, Giliani S, Frattini A, Imberti L, Benerini Gatta L, Ochs HD, Schwarz K, Notarangelo L, Vezzoni P and Spanopoulou E.  Partial V(D)J recombination activity leads to Omenn syndrome. Cell 93: 885-896, 1998
6. FrattiniF, OrchardPJ, SobacchiC, GilianiS, AbinunM,. Mattsson JP, KeelingDJ, AnderssonAK, WallbrandtP, ZeccaL, NotarangeloLD, VezzoniP and VillaA. Defects in the TCIRG1-encoded 116kD subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis. Nature Genet, 25:343-346, 2000
7. Zucchi I, Bini L, Valaperta R, Ginestra A, Albani D, Susani L, Sanchez JC, Liberatori S, Magi B, Raggiaschi R, Hochstrasser DF, Pallini V, Vezzoni P, Dulbecco R.  Proteomic dissection of dome formation in a mammary cell line: role of tropomyosin-5b and maspin. Proc. Natl. Acad. Sci. USA., 98:5608-5613, 2001
8. Frattini A, Blair HC, Sacco MG, Cerisoli F, Faggioli F, Mira Catò E, Pancrazio A, Musio A, Rucci F, Sobacchi C, Sharrow AC, Kalla SE, Buzzone MG, Colombo R, Magli MC, Vezzoni P, Villa A. Rescue of ATPa3-deficient Murine Malignant Osteopetrosis by Hematopoietic Stem Cell Transplantation In Utero. Proc Natl Acad Sci USA, 102:14629-14634, 2005
9. Musio A, Selicorni A, Focarelli ML, Gervasini C, Milani D, Russo S, Vezzoni P, Larizza L. X-linked Cornelia de Lange syndrome owing to SMC1L1 mutations. Nat Genet. 38:528-530, 2006
10. Sobacchi C, Frattini A, Guerrini MM, Abinun M, Pangrazio A, Susani L, Bredius R, Mancini G, Cant A, Bishop N, Grabowski P, Del Fattore A, Messina C, Errigo G, Coxon FP, Scott DI, Teti A, Rogers MJ, Vezzoni P, Villa A, Helfrich MH. Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL. Nat Genet. 39:960-962, 2007